Potentilla grass on diabetes prevention and treatment Role of the Clinical Research

Diabetes (diabetes mellitus, DM) is a chronic, multiple diseases, with more complications and morbidity have increased year by year trend, with cancer, cardiovascular disease was the same as the three diseases worldwide. Potentilla grass (Potentilla discolor Bge), also known as chicken abuse, child day lotus root, chicken Lake, feet, and so on grass, the rose family plant Potentilla grass root zone of grass-wide, are distributed all over the country, the Northeast, North China and other regions There are the same for its plant-wide Potentilla grass Potentilla grass used to do. Root with tannin and flavonoids, sweet, bitter, sex-, heat and cooling blood swelling of detoxification work and governance dysentery, malaria, blood, blood Dengzheng [1]. Shao Changping [2], and so on Potentilla grass mixture to observe the treatment of type 2 diabetes Yin Deficiency evidence of efficacy, Potentilla grass mixture from Potentilla grass, Astragalus, Chinese yam, Cortex, Polygonum multiflorum, and other components of the drug. Random group therapy, oral treatment group Potentilla grass mixture and Desha film, in the control group Desha oral tablets. 80 cases of treatment group, 51 cases of male, female 29 cases; the youngest 39 years old, maximum 68-year-old, with an average age of 55.4; history of diabetes 1 to 5 years in 34 cases, 6 to 10 years in 33 cases, 13 cases more than 10 years, with an average course of disease 6.4 years. Control group of 36 cases, 19 cases of men and women in 17 cases; the youngest 38 years old, maximum 67-year-old, with an average age of 54.3; history of diabetes 1 to 5 years in 15 cases, 6 to 10 years in 17 cases, more than 10 years, 4 cases, the average 6.3 years. No two cases of serious liver, kidney, heart, brain diseases and complications of diabetes, and sex, age, illness, disease, the difference was not statistically significant (P> 0.05). Comparable. Laboratory examination: fasting blood glucose and postprandial blood glucose 2h, quantitative urine sugar, total cholesterol (TC), triglycerides (TG), blood, urine and stool routine, liver and kidney function, and so on. The results showed that the treatment group than those in the treatment of various indicators significantly lower, statistically significant, P <0.01.> 0.05. Potentilla grass mixture treatment of type 2 diabetes Yin Deficiency permit the precise effect, found no obvious side effects. Ying Ma, Shao-Wen Chen [3] Potentilla grass with a certain degree of insulin secretion of 50 cases of type 2 diabetes patients were observed, compared to the changes in blood sugar. The treatment of 50 patients, male 26 cases, 24 cases of female, age 45 ~ 68 (58.0 ± 7.1) years old, the course of 1.5 ~ 14 (7.6 ± 3.6), body mass index (BMI)> 25 to 19 cases, of which the combined light 12 cases of severe hypertension, hyperlipidemia in 20 cases. FBG (11.82 ± 1.35) mmol / L. 40 cases in the control group, 18 cases of men and women in 22 cases, the average age of 46 ~ 69 (58.5 ± 7.1) years old, the course of 2 ~ 15 (7.7 ± 4.1) years, BMI> 25 to 12 cases, of which 9 cases of high blood pressure combined with mild , 5 cases of hyperlipidemia. FBG (11.58 ± 1.30) mmol / L. In the treatment group and control group of age constitute, BMI, FBG, and so there was no significant difference between the two groups comparable. Two groups of patients had regular exercise and strict diet, oral metformin treatment in the control group, treatment group on this basis, at the same time give Potentilla grass 30g / d, on behalf of tea. 30-day course of treatment for 1, 2, after the assessment of treatment efficacy. The overall results of the efficacy of the treatment group was better than the control group, P <0.05. Potentilla grass glucose in the treatment group compared with the control group there was a significant difference (P <0.05). Wang Zhenqing [4] containing Potentilla grass-ling treatment of 105 cases of diabetes in patients with diabetes, in which men and 55 cases, 50 cases of women; age 30 to 63 years old; course of 6 to 24 years; glucose 12 ~ 26mmol / L, blood levels of insulin ( 7.5 ± 4) mU / L; complicated by diabetes 36 cases of kidney disease, diabetic retinopathy in 11 cases, 4 cases of diabetic foot, diabetic peripheral neuropathy in 19 cases, 3 cases of cerebral infarction, 6 cases of coronary heart disease, high blood lipids in 10 cases, 11 cases of high cholesterol. Every 20 days fasting blood glucose measured using real sugar law; cholesterol, triglycerides, using enzyme method; hemorheology indicators, using enzyme method; every 10 days, 1 Ci Chen urine sugar as measured using conventional Law. The results of 71 cases were cured, accounting for 67.6 percent; effect those 30 cases, accounting for 28.6 percent; effective in 2 cases, accounting for 1.9 percent; ineffective in 2 cases, accounting for 1.9 percent. 98.1 percent efficient. Fasting blood glucose, cholesterol, triglycerides, whole blood viscosity, whole blood viscosity reduction and treatment of earlier P <0.01, than the plasma viscosity, fibrinogen and treatment of earlier P <0.05, both statistically significant. Kang Chang-ling [5], and so on the 37 cases of type 2 DM with abnormal lipid metabolism Potentilla grass treatment, 20 cases in which men and women in 17 cases, the average age (60.05 ± 11.58) years old, with an average body mass index (BMI) 23.7 ± 2.5. Pre-treatment of other lipid-lowering drugs out of at least a month, which Application of 32 cases of Shuanggua Lei, sulfonylureas and acarbose drug treatment, 5 cases of application of insulin therapy. All objects better control of blood glucose, fasting blood glucose ≤ 6.5mmol / L, postprandial 2h blood glucose ≤ 10.1mmol / L. Potentilla grass with 30g / d, decoction, and after meals of oral morning. Taking medication before and after weeks 4, 8 were taken on an empty stomach for blood glucose, blood lipids, blood rheology testing. Determination of blood lipids, including triglycerides (TG), cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), apolipoprotein A (ApoA), apolipoprotein B (ApoB ), Including blood rheology viscosity of whole blood, plasma viscosity, fibrinogen, hematocrit. Observation period to monitor the treatment of liver and kidney function. Using statistical analysis of both X ± s said that the group used to compare t check. The results of triglycerides, cholesterol, blood viscosity, plasma viscosity, fibrinogen, hematocrit, apolipoprotein B (ApoB) lower than before treatment. One triglycerides, apolipoprotein B, and the viscosity of whole blood before treatment, the difference was significant (P <0.05), cholesterol, plasma viscosity, fibrinogen, compared with the pre-treatment difference was significant (P <0.01). Kunming Institute of Botany, Chinese Academy of Sciences Laboratory of Chemical Plant [6] Potentilla grass for the first time from the methanol extracts isolated compounds 6, respectively flavonoid glycosides and triterpenes. Chen Keji, and so that [7], flavonoids can affect the function of islet cells, B, the three can be Terpenoids material impact on glucose metabolism. In recent years, many Chinese and foreign scholars from plants, separation has a variety of pharmacological activities of compounds, including flavonoids on quite a number of great importance to and from the point of view of diabetes and its complications mechanism to explore its main mechanism of action is to remove free Based, anti-lipid peroxidation and non-enzymatic glycation damage; impact of β-cell function; around the promotion of cell, tissue and target organ for the use of sugar; anti-inflammatory, and enhance immune function; inhibiting aldose reductase; microcirculation and so on. Such as quercetin [8 to 10], silymarin [11], hesperidin [12] in the removal of free radicals, anti-lipid peroxidation and correct the fat and protein metabolism has been reported. Quercetin can significantly reduce the STZ diabetic rats serum total cholesterol, triglycerides, the lipid peroxide content, while no effect on blood sugar in normal rats. Organization of the kidney on lipid peroxide (LPO) and advanced glycation end products (AGEs), pentosi ˉ dine and lipid peroxide fluorescent adducted significantly inhibit urinary albumin excretion decreased, GBM Stromal hyperplasia and showed some improvements. Li Fu, etc. [10] reported that quercetin on experimental diabetic rat heart protective effect, may be related to the removal of free radicals, such as cholesterol-lowering biological activity. QU to explore in the treatment of diabetic kidney disease mechanisms, silymarin diabetic rats by inhibiting the aorta and kidney glycation and oxidation of non-control of chronic vascular complications of diabetes and diabetic kidney disease. Hesperidin in inhibiting protease glycosylation, the prevention of diabetes complications and Aminoguanidine has a similar effect. , The flavonoids anti-diabetes and its complications pharmacological research for the role of animal testing stage, clinical trials report only a small number. In recent years, scholars at home and abroad, of natural medicine and traditional Chinese medicine attaches great importance to the study. Flavonoids source of drug development, the new extract the active ingredients and pharmacological effects, so that it expanded the scope of clinical applications, and its mechanism of action and pharmacological research is still the focus of future research. Potentilla grass of flavonoids drug side effects, not only reduces blood sugar, can also enhance the role of heat-clearing and detoxifying the body immune function, prevention and treatment DM complications, and its low price, great value for development. With modern medicine, the rapid development of science and technology, it is necessary to do an in-depth study on its mechanism of action, in order to promote the clinical application of the treatment of diabetes and its complications and new drug research and development and provide a theoretical basis.